Systematic analysis of CDR contacts and sequence constraints between T cell receptor αβ chains.
Martina Milighetti, Yuta Nagano, James Henderson, Uri Hershberg, Andreas Tiffeau-Mayer, Anne‐Florence Bitbol, Benny Chain
This study systematically analyzes CDR contacts and sequence constraints between TCR αβ chains using TCR structures and mutual information, showing sequence dependencies and co-evolution patterns.
bioRxiv · May 24, 2024 · PreprintImmunology