Benny Chain

This study profiles T cell repertoires in Lynch syndrome patients to show convergent immune responses during neoplastic progression.

This study examines the T-cell receptor repertoire in wild mice, finding that repertoire diversity varies with age and sex, while richness remains stable.

The paper quantifies T cell response dynamics during primary SARS-CoV-2 infection, showing clone-intrinsic properties drive clonal kinetics and providing insights for vaccine design.

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

This study identifies a distinct senescent-like CD8 TEMRA cell population in older individuals with type 2 diabetes, linked to metabolic inflammation and impaired immune function.

The paper tracks T cell responses over time in the tuberculin skin test to identify Mtb-reactive T cell metaclones that are immunodominant across individuals.

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

This study systematically analyzes CDR contacts and sequence constraints between TCR αβ chains using TCR structures and mutual information, showing sequence dependencies and co-evolution patterns.

The paper introduces a method to reconstruct real-time dynamics from single-cell trajectories by estimating cell density, flux, division, and apoptosis rates, validated on mouse thymus data.

This paper predicts effective drug combinations for treating early- and late-stage severe SARS-CoV-2 infection using an executable network model of host-virus interactions.

This study uses single molecule barcoding with HTS to reveal stochastic heterogeneity in PCR amplification efficiency, independent of sequence or experimental conditions.

This study tracks changes in CD4 T cell receptor repertoires after immunization using short CDR3 sequences, showing distinct repertoires at different time points post-vaccination.