Martina Milighetti

This paper introduces CloneSearch, a method to identify expanding and contracting T cell clones from longitudinal TCR sequencing without requiring antigen-specific information.

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

The paper develops a Treg gene and protein signature to predict disease activity in Juvenile Idiopathic Arthritis using machine learning and flow cytometry.

DiffPaSS improves pairing of interacting protein sequences using differentiable optimization, outperforming existing methods on benchmark datasets.

This study systematically analyzes CDR contacts and sequence constraints between TCR αβ chains using TCR structures and mutual information, showing sequence dependencies and co-evolution patterns.