Author

Luis Zafra‐Puerta

Instituto CajalORCID 0000-0002-1807-7538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

José María SerratosaiD· 2 shared Marina P. SáncheziD· 2 shared Nerea Iglesias‐CabezaiD· 2 shared Alessandro TozziiD· 1 shared Andrea ManciniiD· 1 shared Anna Aurora TaddeiiD· 1 shared Cinzia CostaiD· 1 shared Daniel F. BurgosiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

José María SerratosaORCID

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2 papers

Recent·Most cited

Neuronal Hyperexcitability: A Key to Unravelling Hippocampal Synaptic Dysfunctions in Lafora Disease

Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, , Miriam Sciaccaluga

This study investigates early molecular mechanisms of Lafora disease using a mouse model, finding that neuronal hyperexcitability and impaired synaptic plasticity emerge early and can be mitigated by CBD treatment.

Epilepsia · Dec 17, 2025Peer-reviewedNeuroscience

Gene replacement therapy for Lafora disease in the Epm2a-/- mouse model

Luis Zafra‐Puerta, Daniel F. Burgos, Nerea Iglesias‐Cabeza, Juan González‐Fernández, Gema Sánchez‐Martín, Marina P. Sánchez, José María Serratosa

This study uses gene replacement therapy in Epm2a-/- mice to treat Lafora disease, showing improvements in neurological symptoms and reduced Lafora body formation.

bioRxiv · Dec 14, 2023 · PreprintNeuroscience