Neuronal Hyperexcitability: A Key to Unravelling Hippocampal Synaptic Dysfunctions in Lafora Disease
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, , Miriam Sciaccaluga
This study investigates early molecular mechanisms of Lafora disease using a mouse model, finding that neuronal hyperexcitability and impaired synaptic plasticity emerge early and can be mitigated by CBD treatment.
Epilepsia · Dec 17, 2025Peer-reviewedNeuroscience