Fabrizio Gardoni

This study identifies RNF10-mediated signaling in the dorsal hippocampus as essential for cognitive flexibility by linking NMDAR activation to transcriptional programs that support adaptive behavior.

This study investigates early molecular mechanisms of Lafora disease using a mouse model, finding that neuronal hyperexcitability and impaired synaptic plasticity emerge early and can be mitigated by CBD treatment.

This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.

This study identifies GluN3A-NMDA receptors as negative regulators of GIT1/mTORC1 assembly, showing their role in controlling synaptic protein synthesis and memory formation.

This study identifies CAP2 as a regulator of Cofilin in synaptic plasticity, showing its role in LTP and its disruption in Alzheimer’s disease.