GeneticsGeroSciencePeer-reviewed
Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan
Cheryl Zi Jin Phua, Xiaqing Zhao, Lesly Turcios-Hernandez…·Alaattin Kaya
The paper investigates how knocking out nuclear-encoded mitochondrial genes in yeast affects lifespan, revealing shared mechanisms involving ribosomal proteins, actin dynamics, and proteasome function.
11 citations