Morag A. Lewis

The paper investigates the role of Zfp719 in hearing maintenance in mice, finding that its mutation leads to progressive hearing loss and outer hair cell degeneration.

This study identifies distinct genes and pathways for sensory and metabolic hearing loss using large-scale audiometric phenotyping and sex-stratified analyses.

This study characterizes hearing loss in mice with human MIR96 mutations and identifies a therapeutic candidate that delays hearing loss progression in heterozygous mice.

This study identifies genes and variants associated with self-reported hearing difficulty in older adults using UK Biobank exome sequencing data, finding that both common and rare variants contribute to age-related hearing loss, with sex-specific differences.

The paper identifies and characterizes spontaneous mutations causing deafness in mice from a targeted knockout program, showing these mutations are a common side effect of intensive breeding.

This paper identifies Klhl18 mutant mice with low-frequency progressive hearing loss due to inner hair cell dysfunction, showing abnormal stereocilia and normal outer hair cell function.

This study investigates the effects of Mir183/96/182 mutations on hearing, finding that loss of these microRNAs causes deafness, while their mutations can lead to both loss and gain of function effects.

The paper curates 164 gene-disease pairs for hearing loss, classifying their clinical validity to improve genetic testing accuracy.