Author

Maria Lachgar-Ruiz

King's College LondonORCID 0000-0002-0285-622XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Karen P. SteeliD· 2 shared Morag A. LewisiD· 2 shared Alejandro ToboniD· 1 shared Berta Marcó de la CruziD· 1 shared Carlo Emanuele VillaiD· 1 shared Cristina CheroniiD· 1 shared Elena F. CattaneoiD· 1 shared Erika TenderiniiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Karen P. SteelORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 14, 2026

Zfp719 is a transcription factor important for maintenance of hearing in mice

Jing Chen, Neil J. Ingham, Maria Lachgar-Ruiz…·Karen P. Steel

The paper investigates the role of Zfp719 in hearing maintenance in mice, finding that its mutation leads to progressive hearing loss and outer hair cell degeneration.

DOI 10.64898/2026.06.15.732256

mousebulk RNA-seq

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GeneticsbioRxivPreprintFeb 20, 2024

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations

Morag A. Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico…·Karen P. Steel

This study characterizes hearing loss in mice with human MIR96 mutations and identifies a therapeutic candidate that delays hearing loss progression in heterozygous mice.

1 citation

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintMar 4, 2019

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

Alejandro Tobon, Carlo Emanuele Villa, Cristina Cheroni…·Giuseppe Testa

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

2 citations

humanscRNA-seq

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