Francesca Di Domenico

This study shows that peri-operative pregabalin does not harm experimental outcomes in rat chronic pain models and improves animal welfare.

This study characterizes hearing loss in mice with human MIR96 mutations and identifies a therapeutic candidate that delays hearing loss progression in heterozygous mice.

This study identifies the origin of diffuse noxious inhibitory controls (DNIC) by showing that optogenetic manipulation of brainstem noradrenergic neurons modulates pain thresholds in a pro-pain manner.

The paper identifies and characterizes spontaneous mutations causing deafness in mice from a targeted knockout program, showing these mutations are a common side effect of intensive breeding.

The paper investigates brainstem to spinal cord noradrenergic pathways and their differential effects on spinal neuronal activity through optogenetic activation.

This study investigates the effects of Mir183/96/182 mutations on hearing, finding that loss of these microRNAs causes deafness, while their mutations can lead to both loss and gain of function effects.