NeuroscienceEMBO Molecular MedicinePeer-reviewed
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease
Subhrangshu Guhathakurta, Jin-Il Kim, Levi Adams…·Yoon‐Seong Kim
This study shows that reducing H3K4me3 at the SNCA promoter using CRISPR/dCas9-JARID1A lowers α-synuclein in Parkinson's disease models.