This study shows that gut-initiated α-synucleinopathy spreads via the splanchnic-spinal pathway, not just the vagus nerve, and identifies spinal pathology in human Parkinson's disease.

bioRxiv · Oct 23, 2026 · PreprintNeuroscience

APOE-stratified genome-wide association study suggests potential novel genes for late-onset Alzheimers disease in East-Asian descent

Sarang Kang, Jungsoo Gim, Jiwoon Lee, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Jang Jae Lee, Eun Hyun Seo, Pan-Woo Ko, Ji Yeon Chung, Seong‐Min Choi, Young Min Lee, Jee Hyang Jeong, Kyung Won Park, Min Kyung Song, Ho‐Won Lee, , Kun Ho Lee

This study identifies two new potential susceptibility genes for late-onset Alzheimer's disease in East Asians through APOE-stratified GWAS.

Journal of Alzheimer s Disease · Jun 18, 2021Peer-reviewedGenetic & Genomic Medicine

Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease

Subhrangshu Guhathakurta, Jin-Il Kim, Levi Adams, Sambuddha Basu, Min Kyung Song, Evan R. Adler, Goun Je, Mariana Bernardo Fiadeiro, Yoon‐Seong Kim

This study shows that reducing H3K4me3 at the SNCA promoter using CRISPR/dCas9-JARID1A lowers α-synuclein in Parkinson's disease models.

EMBO Molecular Medicine · Jan 11, 2021Peer-reviewedNeuroscience