Association between mosaic loss of chromosome Y and pulmonary fibrosis susceptibility and severity
Dapeng Wang, Niran Hadad, Samuel Moss, Elena Ana López-Jiménez, Simon R. Johnson, Toby M. Maher, Philip L. Molyneaux, Yajie Zhao, John R. B. Perry, Paul J. Wolters, Jonathan A. Kropski, Gisli R. Jenkins, Nicholas E. Banovich, Iain D. Stewart
This study investigates the association between mosaic loss of chromosome Y (mLOY) and pulmonary fibrosis, finding mLOY correlates with age and telomere length but not disease severity, and suggests a potential link between telomere shortening and mLOY.
bioRxiv · May 25, 2024 · PreprintGenomics