This study identifies four genetic loci, including one novel, with shared causal variants between severe COVID-19 and idiopathic pulmonary fibrosis (IPF), revealing both shared and distinct biological processes.

European Respiratory Journal · May 20, 2022Peer-reviewedGenetic & Genomic Medicine

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

João Fadista, Luke M. Kraven, Juha M Karjalainen, Shea J. Andrews, Frank Geller, The COVID-19 Host Genetics Initiative, J Kenneth Baillie, Louise V. Wain, Gisli R. Jenkins, Bjarke Feenstra

This paper investigates the genetic link between idiopathic pulmonary fibrosis and severe COVID-19, finding a positive genetic correlation and suggesting a causal effect of most IPF risk variants on COVID-19 severity, except for the MUC5B variant which shows protective effects.

EBioMedicine · Mar 1, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

Richard J. Allen, Beatriz Guillén‐Guío, Justin M. Oldham, Shwu‐Fan Ma, Amy Dressen, Megan L. Paynton, Luke M. Kraven, Ma’en Obeidat, Xuan Li, Michael Ng, Rebecca Braybrooke, María Molina‐Molina, Brian D. Hobbs, Rachel K. Putman, Phuwanat Sakornsakolpat, , Louise V. Wain

This study identifies three new genetic loci associated with idiopathic pulmonary fibrosis and confirms 11 previously reported ones, highlighting mTOR signaling and mitotic spindle-assembly genes in disease susceptibility.

American Journal of Respiratory and Critical Care Medicine · Nov 11, 2019Peer-reviewedGenomics