Christopher M. Yellman

This study identifies Kar4 as a key component of the yeast mRNA methyltransferase complex required for both mating and meiosis, with distinct functional roles in these processes.

The paper shows that yeast cells with impaired early anaphase Cdc14 release can complete meiosis without ribosomal DNA disjunction in meiosis I, suggesting this process is not essential for meiosis.

The paper demonstrates a method to replace yeast proteasome genes with human orthologs using homologous recombination and double-strand breaks.