BiochemistryEuropean Journal of Medicinal ChemistryPeer-reviewed
Discovery of dual thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket
Men Thi Hoai Duong, Tomi A. O. Parviainen, Aditya Thiruvaiyaru…·L. Lehtiö
The paper identifies a dual thiobarbiturate-indole inhibitor of the chikungunya virus macrodomain through screening and structural analysis, showing high selectivity over related proteins.
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