Men Thi Hoai Duong

Discovery of dual thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket

The paper identifies a dual thiobarbiturate-indole inhibitor of the chikungunya virus macrodomain through screening and structural analysis, showing high selectivity over related proteins.

A FRET-based high-throughput screening assay for the discovery of Mycobacterium tuberculosis DNA ADP-ribosylglycohydrolase DarG inhibitors

This paper develops a FRET-based high-throughput screening assay to identify DarG inhibitors in M. tuberculosis and identifies pranlukast as a selective inhibitor.

Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

This study identifies pyrrolo-pyrimidine-based Mac1 inhibitors that inhibit MHV and SARS-CoV-2 replication, with some compounds showing IFN-dependent antiviral activity.