Discovery of dual thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket
Men Thi Hoai Duong, Tomi A. O. Parviainen, Aditya Thiruvaiyaru, Tero Ahola, Juha P. Heiskanen, L. Lehtiö
The paper identifies a dual thiobarbiturate-indole inhibitor of the chikungunya virus macrodomain through screening and structural analysis, showing high selectivity over related proteins.
European Journal of Medicinal Chemistry · Jul 22, 2026Peer-reviewedBiochemistry