BiochemistryNucleic Acids ResearchPeer-reviewed
Domain Acquisition by Class I Aminoacyl-tRNA Synthetase Urzymes Coordinated the Catalytic Functions of HVGH and KMSKS Motifs
Guo Qing Tang, Jessica J H Elder, Jordan Douglas, Charles W. Carter
This study examines the energetic coupling of catalytic motifs in LeuRS and its urzyme ancestor, showing how domain acquisition enhances transition-state stabilization.