Evolutionary BiologybioRxivPreprint
Escherichia coli deletes in vivo the same domains from a double-mutant leucyl-tRNA synthetase gene that were deleted in vitro to make the LeuAC urzyme
Guo Qing Tang, Charles W. Carter
This paper shows that E. coli deletes specific domains from a double-mutant leucyl-tRNA synthetase gene in vivo, similar to in vitro deletions that create the LeuAC urzyme, suggesting a mechanism for ancestral enzyme evolution.
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