Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice
Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya, Zoya Antysheva, В. Н. Манских, Anna V. Tvorogova, Diana S. Korshunova, Alvina I. Khamidullina, Marina V. Utkina, Viktor P. Bogdanov, Iuliia P. Baikova, Alyona I. Nikiforova, Eugene A Albert, Denis O. Maksimov, Jing Li, , Victor Vyacheslavovich Tatarskiy
This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.
eLife · Apr 2, 2025Peer-reviewedDevelopmental Biology