Anna V. Tvorogova

This study compares chromatin architecture in iPSC-derived neurons to fetal and mature neurons, finding iPSC-derived neurons resemble fetal neurons and have distinct chromatin features.

This study identifies accelerated aging patterns in 3D genome organization and transcriptome in schizophrenia using Hi-C data and transcriptomic analysis.

This study shows that CPE motifs in the orb 3UTR regulate mRNA stability and are essential for oocyte specification in Drosophila, while their absence leads to nurse cell development.

The paper investigates how Polycomb proteins regulate gene expression in human cortical neurons through long-range chromatin interactions, showing their role in cell-type specification.

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

This study shows that the Eg5 inhibitor SB743921 induces p53-dependent cell cycle arrest, senescence, and death in tumor cells, particularly in TP53-mutated cells, with potential for combinational therapy with senolytic drugs.

The paper maps 3D genome architecture in neuronal and non-neuronal cells, finding reduced compartmentalization and increased long-range polycomb interactions in neurons.