Author

Ekaterina A. Varlamova

Russian Academy of SciencesORCID 0000-0002-8451-1216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Alexandra V. BruteriD· 2 shared Victor Vyacheslavovich TatarskiyiD· 2 shared Alexander Albertovich ShtiliD· 1 shared Alexander V. IvanoviD· 1 shared Alexandra A. DalinaiD· 1 shared Alexey V. FeoktistoviD· 1 shared Alvina I. KhamidullinaiD· 1 shared Alyona I. NikiforovaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Alexandra V. BruterORCID

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2 papers

Recent·Most cited

The sensitivity of acute myeloid leukemia to CDK8/19 inhibitors is determined by their metabolic profile

Ekaterina A. Varlamova, Daria V. Andreeva, Alexandra A. Dalina, Alexander V. Ivanov, Artemy P. Fedulov, Elena V Misnik, Natalia Pavlenko, Alexandra V. Bruter, Victor Vyacheslavovich Tatarskiy

This study identifies that acute myeloid leukemia (AML) sensitivity to CDK8/19 inhibitors is linked to their metabolic profile, specifically glycolytic activity and TCA disruption.

Biology Direct · Sep 14, 2026Peer-reviewedCell Biology

Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya, Zoya Antysheva, В. Н. Манских, Anna V. Tvorogova, Diana S. Korshunova, Alvina I. Khamidullina, Marina V. Utkina, Viktor P. Bogdanov, Iuliia P. Baikova, Alyona I. Nikiforova, Eugene A Albert, Denis O. Maksimov, Jing Li, , Victor Vyacheslavovich Tatarskiy

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

eLife · Apr 2, 2025Peer-reviewedDevelopmental Biology