Victor Vyacheslavovich Tatarskiy

The sensitivity of acute myeloid leukemia to CDK8/19 inhibitors is determined by their metabolic profile

This study identifies that acute myeloid leukemia (AML) sensitivity to CDK8/19 inhibitors is linked to their metabolic profile, specifically glycolytic activity and TCA disruption.

The ASNS inhibitor ASX-173 potentiates L-asparaginase anticancer activity

The paper identifies ASX-173 as a potent ASNS inhibitor that enhances the anti-cancer effects of L-asparaginase in leukemia and shows its potential across multiple cancer types.

Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells

This study shows that the Eg5 inhibitor SB743921 induces p53-dependent cell cycle arrest, senescence, and death in tumor cells, particularly in TP53-mutated cells, with potential for combinational therapy with senolytic drugs.