Joseph Brancale

Liver Disease Reveals KIF12 as a Critical Regulator of Mitochondria, Lysosome and Cilia Localization

This study identifies KIF12 as critical for organelle localization in cholangiocytes, showing its dysfunction leads to mitochondrial, lysosomal, and cilia mislocalization in liver disease.

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.

A Single Cell Gene Expression Atlas of 28 Human Livers

This study integrates single-cell RNA-sequencing data from 28 human livers to create a comprehensive gene expression atlas accessible via a web portal.