Lanuza A.P. Faccioli

This study identifies YY1 phosphorylation as a key mechanism linking non-apoptotic caspase-8 signaling to METRN induction and MASH fibrosis.

DGAT imputes spatial protein expression from transcriptomics-only data, revealing cell states and tissue organization not visible from RNA alone.

This study identifies KIF12 as critical for organelle localization in cholangiocytes, showing its dysfunction leads to mitochondrial, lysosomal, and cilia mislocalization in liver disease.

This study identifies hLMR1, a human-specific lncRNA, as a suppressor of hepatic amino acid catabolism and ureagenesis, linking its dysregulation to metabolic dysfunction in MAFLD.

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.