Michael von Bergwelt‐Baildon

The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.

This study shows L-asparaginase reduces B cell proliferation and function, induces a regulatory B cell phenotype, and may have immunosuppressive effects on non-malignant B cells.

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.