HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures
Oier Pastor-Alonso, Irene Durá, Sara Bernardo-Castro, Emilio Varea, Teresa Muro‐García, Soraya Martín‐Suárez, Juan Manuel Encinas, José Ramón Pineda
The paper shows that seizures in mice disrupt the hippocampal neurogenic niche by inducing reactive neural stem cells via the EGFR pathway, and inhibiting EGFR improves neurogenesis.
bioRxiv · Nov 2, 2022 · PreprintNeuroscience