Oier Pastor-Alonso

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons

This study creates a 3D multi-omic atlas of developing human basal ganglia and inhibitory neurons, revealing lineage-specific 3D genomic dynamics and regulatory programs associated with neuropsychiatric disease risk.

Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

This study shows that adult hippocampal neural stem cells (aNSCs) form in the early postnatal dentate gyrus and require cyclin D2 for their development.

HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures

The paper shows that seizures in mice disrupt the hippocampal neurogenic niche by inducing reactive neural stem cells via the EGFR pathway, and inhibiting EGFR improves neurogenesis.

Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

The paper investigates epigenomic and 3D chromatin conformation changes in human frontal cortex and hippocampus development using sn-m3C-seq, finding distinct chromatin conformations in neurons and glial cells and linking risk variants to regulatory regions.