AI-Guided CAR Designs and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
Md Sufyan Ansari, Varnit Chauhan, Aashi Singh, Areej Akhtar, Nisha Chaudhary, Reegina Tyagi, Divya, Kashif Husain, Sheetal Sharma, Raquib Alam, Md Shakir, Mehak Pracha, Samreen Anjum, Mohd Nadeem, Md Imam Faizan, , Tanveer Ahmad
This study designs and evaluates AI-optimized CAR-T cells with AKT3 degradation to improve persistence and overcome antigen escape in cancer therapy.
bioRxiv · Jun 12, 2025 · PreprintCancer Biology