Author

Leigh A. Kotzé

South African Medical Research CouncilORCID 0000-0002-2019-8777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Alexa PetruccianiiD· 2 shared Alexis HoerteriD· 2 shared Elsje PienaariD· 2 shared Nelita du PlessisiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersSystems Biology

Alexa PetruccianiORCID

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2 papers

Recent·Most cited

Systems BiologyPLoS Computational BiologyPeer-reviewedJul 12, 2024

Agent-based model predicts that layered structure and 3D movement work synergistically to reduce bacterial load in 3D in vitro models of tuberculosis granuloma

Alexa Petrucciani, Alexis Hoerter, Leigh A. Kotzé…·Elsje Pienaar

The paper uses agent-based simulations to show that 3D spheroid structures and cell movement enhance bacterial control in tuberculosis granuloma models.

8 citations

experimental assay

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Systems BiologybioRxivPreprintMar 13, 2023

In silico agent-based modeling approach to characterize multiple in vitro tuberculosis infection models

Alexa Petrucciani, Alexis Hoerter, Leigh A. Kotzé…·Elsje Pienaar

This paper introduces an agent-based model to simulate and compare traditional and spheroid in vitro tuberculosis infection models, showing heterogeneous outputs and predictive capabilities.

DOI 10.1101/2023.03.13.532338

experimental assaybenchmarking

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