Nelita du Plessis

This study uses spatial transcriptomics to identify a hypoxia-associated SPP1-enriched microenvironment in pediatric TB granulomas that may contribute to incomplete bacterial clearance.

This study maps human pulmonary T-cell immunity across TB infection/disease using single-cell transcriptomics and functional T-cell cloning, identifying protective immune features and a platform for TB vaccine development.

This study examines how BCG vaccination at birth affects MR1T cell TCR usage and function in infants, finding increased type I interferon response and a TCR cluster enriched in vaccinated infants.

The paper shows that Mtb immunization protects against BCG infection despite inducing M-MDSC, and ATRA reduces M-MDSC to enhance immunity.

This study investigates the role of PKCδ in macrophage immunomodulation during Mtb infection, finding that its deficiency leads to increased Mtb burden and exacerbated pathology.

The paper uses agent-based simulations to show that 3D spheroid structures and cell movement enhance bacterial control in tuberculosis granuloma models.

This paper introduces an agent-based model to simulate and compare traditional and spheroid in vitro tuberculosis infection models, showing heterogeneous outputs and predictive capabilities.

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.