Antagonism and selective modulation of the human glucocorticoid receptor both reduce recruitment of p300/CBP and the Mediator complex
Laura Van Moortel, Annick Verhee, René Houtman, Diana Melchers, Louis Delhaye, Jonathan Thommis, Kris Gevaert, Sven Eyckerman, Karolien De Bosscher
The paper investigates how different GR ligands affect coregulator recruitment, finding that antagonists and selective modulators reduce interactions with p300/CBP and the Mediator complex compared to full agonists.
bioRxiv · May 15, 2023 · PreprintMolecular Biology