Sven Eyckerman

This study expands a modular cloning platform to enable rapid, customizable construct assembly for MAPPIT assays, demonstrating its application in studying multiple protein-protein interactions.

The paper shows that many reported RNA-chromatin interactions are technical artifacts caused by DNA off-targeting, not true biological interactions.

The paper uses BioID proximity labeling to show p53 interacts with PML nuclear bodies and SUMOylation proteins in HEK293 cells, linking these interactions to differences in p53 transcriptional activity compared to HCT116 cells.

This study maps the proximity interactome of NR2E3 and its G56R variant using TurboID, revealing interactions with retinal development complexes and identifying BCOR as enriched in the mutant network.

This study identifies SopB-associated host proteins using Virotrap, revealing SopB's interaction with ESCRT-0 and its role in Salmonella's manipulation of host endosomal trafficking.

This paper introduces a 96-well ultrafiltration method for isolating extracellular vesicles from conditioned medium, improving purity and reproducibility for proteomic analysis.

The paper identifies NESPR, an adrenergic-specific lncRNA, as a regulator of neuroblastoma cell identity that prevents cell death by attenuating stress.

This study shows that inhibiting CCR1 enhances the effectiveness of glucocorticoid therapy in multiple myeloma by reversing resistance mechanisms.

The paper investigates N-terminal proteoforms and finds they can engage in different protein complexes compared to their canonical counterparts.

The paper investigates how different GR ligands affect coregulator recruitment, finding that antagonists and selective modulators reduce interactions with p300/CBP and the Mediator complex compared to full agonists.