Pharmacology & ToxicologybioRxivPreprint
Prokineticin-2 Upregulates GDNF in Astrocytes and Pharmacological Modulation of PK2 Receptors offers Neuroprotection in Experimental Models of Parkinson's Disease
Jie Denny Luo, Griffin Clabaugh, Matthew P Neal…·Anumantha G. Kanthasamy
This study shows that PK2 signaling increases GDNF in astrocytes and that modulating PK2 receptors protects neurons in Parkinson's disease models.
DOI 10.1101/2025.09.08.674934