Laurent Désaubry

Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

Loss of Flotillin-2 enhances trastuzumab emtansine internalization and cytotoxicity by relieving negative regulation of HER2 internalization in HER2-amplified cancers

This study shows that reducing Flotillin-2 increases T-DM1 internalization and cytotoxicity in HER2-amplified cancers by enhancing HER2 ubiquitination and internalization.

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

Prokineticin-2 Upregulates GDNF in Astrocytes and Pharmacological Modulation of PK2 Receptors offers Neuroprotection in Experimental Models of Parkinson's Disease

This study shows that PK2 signaling increases GDNF in astrocytes and that modulating PK2 receptors protects neurons in Parkinson's disease models.

Distinct Response Patterns to PHB Modulators in B Cell Lymphoma Models

The paper evaluates five PHB-targeting molecules in B cell lymphoma models, showing varied antiproliferative and cytotoxic effects across different cell lines.

Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination

This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.