Author

Yuanjia Tang

Shanghai Jiao Tong UniversityORCID 0000-0002-2044-5424Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Nan SheniD· 4 shared Huihua DingiD· 3 shared Leah Claire KottyaniD· 3 shared Matthew T. WeirauchiD· 3 shared Wanling YangiD· 3 shared Yongfei WangiD· 3 shared Bahram NamjouiD· 2 shared Chao Yao· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Nan ShenORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 11, 2021

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery

Tian Zhou, Xinyi Zhu, Zhizhong Ye…·Nan Shen

The paper identifies a dysfunctional enhancer linked to IRF8 expression through CRISPRa screening and shows its regulation by a lncRNA and DNA methylation.

DOI 10.1101/2021.06.11.448156

humanexperimental assay

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GeneticsNature CommunicationsPeer-reviewedFeb 3, 2021

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

Yongfei Wang, Yan Zhang, Zhiming Lin…·Wanling Yang

This study identifies 38 novel SLE loci and shows genetic heterogeneity across ancestral groups, highlighting antibody production as a potential mechanism for disease disparities.

238 citationstop 1%

humanGWAS summary statistics

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GeneticsNature CommunicationsPeer-reviewedJan 8, 2021

SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

Guojun Hou, Isaac T. W. Harley, Xiaoming Lu…·Nan Shen

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.

74 citationstop 1%

humanDNA methylation

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Genetic & Genomic MedicineAnnals of the Rheumatic DiseasesPeer-reviewedDec 3, 2020

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

Xianyong Yin, Kwang-Woo Kim, Hiroyuki Suetsugu…·Sang‐Cheol Bae

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

172 citationstop 5%

humanGWAS summary statistics

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