Author

Guojun Hou

Shanghai Jiao Tong UniversityORCID 0000-0003-3974-4667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:variant effect prediction· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Nan SheniD· 3 shared Ya GuoiD· 3 shared Bahram NamjouiD· 2 shared Chao Yao· 2 shared Hong XuiD· 2 shared Huihua DingiD· 2 shared Jianyang MaiD· 2 shared John B. HarleyiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Nan ShenORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintJan 5, 2026

DNA sequence quantitatively encodes CTCF-binding affinity at genome scale

Zihang Yin, Yefan Wang, Guojun Hou…·Ya Guo

The paper experimentally measures CTCF-binding affinity across 276,765 human DNA sequences and develops a deep learning model to predict and interpret binding strength based on sequence features.

1 citation

humanDNA methylation

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GeneticsbioRxivPreprintJun 11, 2021

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery

Tian Zhou, Xinyi Zhu, Zhizhong Ye…·Nan Shen

The paper identifies a dysfunctional enhancer linked to IRF8 expression through CRISPRa screening and shows its regulation by a lncRNA and DNA methylation.

DOI 10.1101/2021.06.11.448156

humanexperimental assay

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GeneticsNature CommunicationsPeer-reviewedJan 8, 2021

SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

Guojun Hou, Isaac T. W. Harley, Xiaoming Lu…·Nan Shen

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.

74 citationstop 1%

humanDNA methylation

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