Author

Huihua Ding

Shanghai Jiao Tong UniversityORCID 0000-0002-7530-8953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Leah Claire KottyaniD· 3 shared Matthew T. WeirauchiD· 3 shared Nan SheniD· 3 shared Yuanjia TangiD· 3 shared Bahram NamjouiD· 2 shared Chao Yao· 2 shared Guojun HouiD· 2 shared Hong XuiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Leah Claire KottyanORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 11, 2021

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery

Tian Zhou, Xinyi Zhu, Zhizhong Ye…·Nan Shen

The paper identifies a dysfunctional enhancer linked to IRF8 expression through CRISPRa screening and shows its regulation by a lncRNA and DNA methylation.

DOI 10.1101/2021.06.11.448156

humanexperimental assay

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GeneticsNature CommunicationsPeer-reviewedJan 8, 2021

SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

Guojun Hou, Isaac T. W. Harley, Xiaoming Lu…·Nan Shen

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.

74 citationstop 1%

humanDNA methylation

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Genetic & Genomic MedicineAnnals of the Rheumatic DiseasesPeer-reviewedDec 3, 2020

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

Xianyong Yin, Kwang-Woo Kim, Hiroyuki Suetsugu…·Sang‐Cheol Bae

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

172 citationstop 5%

humanGWAS summary statistics

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