Adeno-Associated Virus-Induced Neurotoxicity is Prevented by CpG Depletion
Connor E. Dunn, Brigett V. Carvajal, Jie Ma, Guadalupe Castaneda-Hernandez, Ai Vy Nguyen, Caroline Jung, Christos Michael Suriano, Lisa M. Boulanger
This study shows that reducing CpG motifs in AAV genomes prevents neurotoxicity in mice and provides a tool to design CpG-depleted AAV vectors.
Molecular Therapy Advances · Feb 19, 2026Peer-reviewedNeuroscience