NeuroscienceMolecular Therapy AdvancesPeer-reviewed
Adeno-Associated Virus-Induced Neurotoxicity is Prevented by CpG Depletion
Connor E. Dunn, Brigett V. Carvajal, Jie Ma…·Lisa M. Boulanger
This study shows that reducing CpG motifs in AAV genomes prevents neurotoxicity in mice and provides a tool to design CpG-depleted AAV vectors.
DOI 10.1016/j.omta.2026.201703