Caroline Jung

This study shows that reducing CpG motifs in AAV genomes prevents neurotoxicity in mice and provides a tool to design CpG-depleted AAV vectors.

This paper investigates cerebellar contributions to reversal learning by mapping brainwide networks through c-Fos activation and identifies distinct effects of lobule VI and crus I inactivation.

This study shows that AAV triggers dendritic complexity loss in the cortex via TLR9, independent of capsid or transgene, and identifies TLR9 inhibitors as potential safety improvements.