Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia
Nina Kurrle, Philipp Makowka, Vera Schlipfenbacher…·Hubert L. Serve
This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.