MicrobiologyJournal of Medical VirologyPeer-reviewed
Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors
Erika Zodda, Mònica Pons, Natàlia DeMoya‐Valenzuela…·Timothy M. Thomson
This study shows that SARS-CoV-2's ORF9b protein activates inflammasomes and caspase-1, and small molecules inhibiting its homodimerization reduce inflammation and restore interferon signaling.
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