Author

Hisham Mazal

Max Planck Institute for the Science of LightORCID 0000-0002-2071-9552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Daniel BollschweileriD· 2 shared Franz-Ferdinand WieseriD· 2 shared Vahid SandoghdariD· 2 shared Alexandra SchambonyiD· 1 shared David ScheereriD· 1 shared Dorit Levy· 1 shared Gilad HaraniD· 1 shared Inbal RiveniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Daniel BollschweilerORCID

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3 papers

Recent·Most cited

Cryogenic light microscopy of vitrified samples with Angstrom precision

Hisham Mazal, Franz-Ferdinand Wieser, Daniel Bollschweiler, Vahid Sandoghdar

This paper introduces a method for cryogenic light microscopy with Angstrom precision to study membrane proteins in near-native conditions.

Proceedings of the National Academy of Sciences · Dec 3, 2025Peer-reviewedBiophysics

Cryogenic light microscopy with Angstrom precision deciphers structural conformations of PIEZO1

Hisham Mazal, Franz-Ferdinand Wieser, Daniel Bollschweiler, Alexandra Schambony, Vahid Sandoghdar

This study uses cryogenic light microscopy to determine three conformational states of PIEZO1 in the cell membrane, revealing structural changes associated with channel opening.

Science Advances · Aug 20, 2025Peer-reviewedBiophysics

Enzyme activation by urea reveals the interplay between conformational dynamics and substrate binding:a single-molecule FRET study

David Scheerer, Dorit Levy, Remi Casier, Inbal Riven, Hisham Mazal, Gilad Haran

This study uses single-molecule FRET to show urea activates adenylate kinase by promoting an open conformation and reducing AMP inhibition, revealing the interplay between conformational dynamics and substrate binding.

Chemical Science · Jan 1, 2025Peer-reviewedBiophysics