A Stochastic Mechanism Drives Fast Substrate Translocation in the AAA+ Machine ClpB
Remi Casier, Dorit Levy, Inbal Riven, Yoav Barak, Gilad Haran
The paper uses single-molecule FRET to show ClpB translocates substrates rapidly and stochastically, challenging previous models of ATP-driven mechanical work.
Nature Communications · Jan 21, 2026Peer-reviewedBiophysics