Enzyme activation by urea reveals the interplay between conformational dynamics and substrate binding:a single-molecule FRET study
David Scheerer, Dorit Levy, Remi Casier, Inbal Riven, Hisham Mazal, Gilad Haran
This study uses single-molecule FRET to show urea activates adenylate kinase by promoting an open conformation and reducing AMP inhibition, revealing the interplay between conformational dynamics and substrate binding.
Chemical Science · Jan 1, 2025Peer-reviewedBiophysics