Author

Alexander L. Ticho

Mayo ClinicORCID 0000-0002-2115-010XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akhilesh PandeyiD· 1 shared Amro M. AbdelrahmaniD· 1 shared Anna Splinter· 1 shared Brandon A. WilbanksiD· 1 shared Danielle Marie CarlsoniD· 1 shared Dong‐Gi MuniD· 1 shared Enis ÖzmertiD· 1 shared Erik JesseniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Akhilesh PandeyORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

ESCRT-dependent YAP degradation by AKT blockade overcomes adaptive resistance to RAS(ON) inhibition in pancreatobiliary cancer

Jack W. Sample, Enis Özmert, Brandon A. Wilbanks, Danielle Marie Carlson, Hidemi Nishi, Amro M. Abdelrahman, Erik Jessen, Meina Cai, Dong‐Gi Mun, Hendrien Kuipers, Anna Splinter, Alexander L. Ticho, Nathan W. Werneburg, Akhilesh Pandey, Mark Joseph Truty, , Rory L. Smoot

This study identifies AKT as a regulator of YAP stability and shows that AKT inhibition triggers ESCRT-dependent YAP degradation, enhancing the efficacy of RAS inhibition in pancreatobiliary cancers.

bioRxiv · Oct 20, 2026 · PreprintCancer Biology