Secreted Protein Production is Improved by Controlling Endoplasmic Reticulum Stress Associated Protein Degradation
R. Chauncey Splichal, Christina Chan, S. Patrick Walton
The paper shows that increasing proteasomal activity improves secreted protein production in ER-stressed cells, while autophagy inhibition also enhances secretion.
bioRxiv · Aug 5, 2025 · PreprintBioengineering