S. Patrick Walton

This study shows that palmitate-activated IRE1-XBP1 signaling reduces DNA damage in triple-negative breast cancer cells by regulating H2A.X and DNA-damage-response transcripts.

This study develops CRISPR-Cas9 engineered HEK293T cells for stable production of surface-engineered extracellular vesicles, showing improved consistency and scalability compared to transient transfection.

This paper introduces a scalable filtration method to isolate exomeres, showing they are stable, miRNA-rich NVEPs that could improve RNA delivery.

The paper shows that increasing proteasomal activity improves secreted protein production in ER-stressed cells, while autophagy inhibition also enhances secretion.